Job Description

Our client is currently seeking a motivated and creative synthetic chemist to join their growing medicinal chemistry team. As an integral member of the Preclinical Development department, the candidate will contribute to hit-to-lead and lead optimization efforts across multiple programs, leveraging our vast chemical datasets and proprietary platforms to power state-of-the-art small molecule design and synthesis. In this interdisciplinary role, the candidate will work closely with teams from different functional areas in both Preclinical Development and Computational and Data Science (CDS) departments.

The core responsibilities of this position are:

• Design and synthesize bio-active molecules for programs in hit-to-lead and/or lead optimization.
• Interpret large sets of potency, ADME and DMPK data to uncover structure-activity relationships.
• Optimize the properties for molecules across multiple series for in-vivo exposure and efficacy.
• Work closely with Machine Learning and AI teams to integrate predictive and generative modelling with compound design.
• Manage and/or assist in managing external chemistry efforts (CROs).

Required Qualifications:

• Ph.D. or postdoc in organic or synthetic chemistry plus 2-5 years of experience in the biotech or pharmaceutical industries OR
• Bachelor’s or Master’s degree in organic or synthetic chemistry plus 10-15 years of experience in the biotech or pharmaceutical industries
• Can demonstrate scientific initiative and creativity in multi-step synthesis and/or reaction methodology through primary authored peer-reviewed publications or patents.

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